News

On the anti-amyloidogenic activity of natural polyphenols and their metabolites

Posted by on Gen 26, 2016 in News

On the anti-amyloidogenic activity of natural polyphenols and their metabolites

Transthyretin (TTR) is an amyloidogenic protein, the amyloidogenic potential of which is enhanced by a number of specific point mutations. The ability to inhibit TTR fibrillogenesis is known for several classes of compounds, including natural polyphenols, which protect the native state of TTR by specifically interacting with its thyroxine binding sites. Comparative analyses of the interaction and of the ability to protect the TTR native state for polyphenols, both stilbenoids and flavonoids, and some of their main metabolites have been carried out. A main finding of this investigation was the...

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New insights into the bioavailability of red raspberry anthocyanins and ellagitannins

Posted by on Gen 26, 2016 in News

New insights into the bioavailability of red raspberry anthocyanins and ellagitannins

Red raspberries, containing ellagitannins and cyanidin-based anthocyanins, were fed to volunteers and metabolites appearing in plasma and urine were analysed by UHPLC-MS. Anthocyanins were not absorbed to any extent with sub nmol/L concentrations of cyanidin-3-O-glucoside and a cyanidin-O-glucuronide appearing transiently in plasma. Anthocyanins excreted in urine corresponded to 0.007% of intake. More substantial amounts of phase II metabolites of ferulic acid and isoferulic acid, along with 4′-hydroxyhippuric acid, potentially originating from pH-mediated degradation of cyanidin in the...

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A new synthesis for gamma-valerolactones.

Posted by on Gen 26, 2016 in News

A new synthesis for gamma-valerolactones.

Valerolactones are the most interesting endpoint of the microbial conversion of dietary-derived flavan-3-ols in human gut. With the precious help of our colleagues with organic chemistry expertise, we maneged a new synthesis for these elusive compounds, that till be used to test their bioactivity potential. The asymmetric synthesis of a set of hydroxyphenyl γ-valerolactones was achieved starting from 2-silyloxyfuran and alkoxy-substituted benzaldehydes as common precursors. Key synthesis steps included an enantioselective vinylogous Mukaiyama aldol reaction and a Barton–McCombie...

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Blue economy, from a polyphenol perspective.

Posted by on Gen 26, 2016 in News

Blue economy, from a polyphenol perspective.

The development of a multi-purpose four step-cascading biorefinery scheme for the valorization of red grape pomace (GP) was proposed. The consecutive processes were respectively dedicated to (a) the recovery of polyphenols by supercritical CO2 extraction, (b) the production of volatile fatty acids (VFAs) by anaerobic acidogenic digestion, (c) the exploitation of produced VFAs as the precursors for the biotechnological production of polyhydroxyalkanoates (PHAs) and (d) the production of a CH4-rich biogas by the anaerobic digestion of solid leftovers from the acidogenic process. More than 2.7 g...

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In Vitro Bioaccessibility of Phenolic Acids from a Commercial Aleurone-Enriched Bread Compared to a Whole Grain Bread

Posted by on Gen 26, 2016 in News

In Vitro Bioaccessibility of Phenolic Acids from a Commercial Aleurone-Enriched Bread Compared to a Whole Grain Bread

Wheat aleurone, due to its potentially higher bioaccessibility and bioavailability of micronutrients and phenolic acids, could represent a useful ingredient in the production of commonly consumed cereal-based food. The aim of the present study was to investigate the in vitro bioaccessibility of phenolic acids both from an aleurone-enriched bread and from a whole grain bread. The two bread samples were firstly characterized for the phenolic acid content. An in vitro digestion was then performed in order to evaluate the release of phenolic acids. The results obtained suggest that the...

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From biodiversity to beerdiversity: the case of italian hop

Posted by on Gen 26, 2016 in News

From biodiversity to beerdiversity: the case of italian hop

What about a good, fresh, tasty craft beer? You need a good barley malt, a nice yeast strain and a lot of passion, but you cannot overlook the availability of fine, aromatic or bitter Humulus lupulus cones. The growing focus on local brewing and the widening of beer marketplaces are increasing the interest for hops endowed with peculiar phytochemical profiles and for new cultivation zones, in order to produce new varieties with unique bouquets. Both these goals may be alleviated by the recourse to genetic material from wild accessions (to be introduced directly in cultivation or to be...

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Let the children play!

Posted by on Ott 8, 2015 in News

Let the children play!

The aim of this study was observing and improving children’s eating habits through an edutainment technological platform. A single-group education intervention was carried out in primary schools in Parma and Milano, Italy. A total of 76 children (32 females and 44 males, 8–10 years old) were involved in a 3-month nutritional program including lessons and educational videogames. Intakes of fruits, vegetables, juices and dietary total antioxidant capacity (TAC) were measured using 3-day food diaries before and after the intervention. The daily total consumption of fruit and vegetables...

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Gastrointestinal stability of urolithins

Posted by on Ott 8, 2015 in News

Gastrointestinal stability of urolithins

are bioactive ellagitannin-derived metabolites showing a wide phenotypic variation in their production by the gut microbiota. This work represents a first in vitro step toward the development of new strategies focused on the oral supplementation of urolithins with the aim of overcoming their selective production and making their putative health benefits available for the whole population. In order to study their gastrointestinal stability, urolithin A, urolithin B, and urolithin B-glucuronide, as well as ellagic acid, were subjected to a simulated gastrointestinal digestion model consisting...

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Urolithins, ephrins and prostate cancer cells

Posted by on Ott 8, 2015 in News

Urolithins, ephrins and prostate cancer cells

For once, let’s jump at the conclusions: the mechanisms behind the cancer preventive properties of foods rich in flavan-3-ols and caffeoylquinic acids are not associated with metabolic pathways directly linked to the Eph-ephrin system. However, the ellagitannin-derived colonic metabolite urolithin D was able to exert remarkable and selective EphA-ephrin-A inhibition, which might impact on prostate cancer prevention. These are the key findings of our latest paper published by Molecular Nutrition and Food Research. Giorgio, C., Mena, P., Del Rio, D., Brighenti, F., Barocelli, E.,...

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On teaching human nutrition in Italy

Posted by on Ott 8, 2015 in News

On teaching human nutrition in Italy

As a broad range of professionals in clinical and nonclinical settings requires some expertise in human nutrition, the university system must offer academic courses tailored to these different specific needs. In the Italian university system there is still uncertainty with regard to the learning objectives regarding human nutrition. In the ministerial decrees defining the criteria for establishing university courses, the indications about education in human nutrition are rather inconsistent, sometimes detailed, but often just mentioned or even only implied. Education in human nutrition...

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